NAVRACHANA UNIVERSITY

Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress

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dc.contributor.author Baxi, D. B.
dc.contributor.author Singh, P. K.
dc.contributor.author Vachhrajani, K. D.
dc.contributor.author Ramachandran, A. V.
dc.date.accessioned 2016-03-12T06:10:00Z
dc.date.available 2016-03-12T06:10:00Z
dc.date.issued 2012
dc.identifier.citation D. B. Baxi , P. K. Singh , K. D. Vachhrajani and A. V. Ramachandran (2013). Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress. Climacteric. 2013 Apr;16(2):274-83 en_US
dc.identifier.other 10.3109/13697137.2012.682108
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/166
dc.description Climacteric. 2013 Apr;16(2):274-83. doi: 10.3109/13697137.2012.682108. en_US
dc.description.abstract Objective The present study aims to determine the potential of melatonin supplementation in ameliorating tissue oxidative stress, elevated serum corticosterone and hepatic and renal dysfunction. Materials and methods Adult Wistar rats, either ovariectomized or sham-operated, served as experimental or control groups, respectively. Rats received either melatonin, estrogen, progesterone or a combination of melatonin and estrogen for a period of 15 days. Tissue oxidative stress, serum markers of hepatic and renal dysfunction and serum corticosterone level formed the parameters of assay in all groups at the end of the treatment schedule. Results Ovariectomized rats showed signifi cant increases in levels of tissue lipid peroxidation, serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, alkaline phosphatase, acid phosphatase and corticosterone and signifi cant decrement in enzymatic and non-enzymatic antioxidant status. All parameters showed maximal reversal to control levels on supplementation with high-dose melatonin or estrogen melatonin treatment. Conclusion Melatonin supplementation proved better than estrogen replacement therapy, with the higher dose being more effective in preventing ovariectomy-induced increases in oxidative stress and serum levels of marker parameters of hepatic and renal dysfunction and corticosterone titer. Overall, melatonin supplementation therapy qualifi es as a more potent and safe alternative to estrogen replacement therapy in alleviating postmenopausal increases in oxidative stress and hepatic and renal dysfunction. en_US
dc.language.iso en en_US
dc.publisher International Menopause Society en_US
dc.subject Melatonin en_US
dc.subject Oxidative Stress en_US
dc.subject Corticosterone en_US
dc.subject Estrogen Replacement Therapy en_US
dc.subject Ovariectomy en_US
dc.title Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress en_US
dc.type Article en_US


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