dc.contributor.author |
Baxi, D. B. |
|
dc.contributor.author |
Singh, P. K. |
|
dc.contributor.author |
Vachhrajani, K. D. |
|
dc.contributor.author |
Ramachandran, A. V. |
|
dc.date.accessioned |
2016-03-12T06:10:00Z |
|
dc.date.available |
2016-03-12T06:10:00Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
D. B. Baxi , P. K. Singh , K. D. Vachhrajani and A. V. Ramachandran (2013). Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress. Climacteric. 2013 Apr;16(2):274-83 |
en_US |
dc.identifier.other |
10.3109/13697137.2012.682108 |
|
dc.identifier.uri |
http://27.109.7.66:8080/xmlui/handle/123456789/166 |
|
dc.description |
Climacteric. 2013 Apr;16(2):274-83. doi: 10.3109/13697137.2012.682108. |
en_US |
dc.description.abstract |
Objective The present study aims to determine the potential of melatonin supplementation in ameliorating
tissue oxidative stress, elevated serum corticosterone and hepatic and renal dysfunction.
Materials and methods Adult Wistar rats, either ovariectomized or sham-operated, served as experimental
or control groups, respectively. Rats received either melatonin, estrogen, progesterone or a combination of
melatonin and estrogen for a period of 15 days. Tissue oxidative stress, serum markers of hepatic and renal
dysfunction and serum corticosterone level formed the parameters of assay in all groups at the end of the
treatment schedule.
Results Ovariectomized rats showed signifi cant increases in levels of tissue lipid peroxidation, serum levels
of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, alkaline phosphatase, acid phosphatase
and corticosterone and signifi cant decrement in enzymatic and non-enzymatic antioxidant status. All parameters
showed maximal reversal to control levels on supplementation with high-dose melatonin or estrogen
melatonin treatment.
Conclusion Melatonin supplementation proved better than estrogen replacement therapy, with the higher
dose being more effective in preventing ovariectomy-induced increases in oxidative stress and serum levels of
marker parameters of hepatic and renal dysfunction and corticosterone titer. Overall, melatonin supplementation
therapy qualifi es as a more potent and safe alternative to estrogen replacement therapy in alleviating
postmenopausal increases in oxidative stress and hepatic and renal dysfunction. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
International Menopause Society |
en_US |
dc.subject |
Melatonin |
en_US |
dc.subject |
Oxidative Stress |
en_US |
dc.subject |
Corticosterone |
en_US |
dc.subject |
Estrogen Replacement Therapy |
en_US |
dc.subject |
Ovariectomy |
en_US |
dc.title |
Melatonin supplementation in rat ameliorates ovariectomy-induced oxidative stress |
en_US |
dc.type |
Article |
en_US |