NAVRACHANA UNIVERSITY

Melatonin supplementation therapy as a potent alternative to ERT in ovariectomized rats

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dc.contributor.author Baxi, D. B.
dc.contributor.author Singh, P. K.
dc.contributor.author Vachhrajani, K.
dc.contributor.author Ramachandran, A. V.
dc.date.accessioned 2016-03-12T06:23:52Z
dc.date.available 2016-03-12T06:23:52Z
dc.date.issued 2012
dc.identifier.citation D. Baxi , P. K. Singh , K. Vachhrajani and A. V. Ramachandran (2012). Melatonin supplementation therapy as a potent alternative to ERT in ovariectomized rats. Climacteric.2012 Aug;15(4):382-92. en_US
dc.identifier.other 10.3109/13697137.2011.618565
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/167
dc.description Climacteric. 2012 Aug;15(4):382-92. doi: 10.3109/13697137.2011.618565 en_US
dc.description.abstract Aim To evaluate the effi cacy of melatonin supplementation therapy as an alternative to estrogen replacement therapy in an ovariectomized rat model and to assess diabetogenic metabolic dysregulation caused by estrogen defi ciency in postmenopausal individuals. Methods Ovariectomized adult Wistar rats were treated with either estrogen/progesterone, melatonin or a combination of estrogen and melatonin. Body weight gain, feed effi ciency, serum glucose, insulin, glucose tolerance and insulin response, serum and tissue lipids, tissue glycogen contents and activities of glycogen phosphorylase and glucose-6-phosphatase were analyzed in all the experimental groups. Results Ovariectomized animals showed increased body weight gain, feed effi ciency, fasting insulin resistance, greater area under curve for the glucose tolerance test, higher serum and tissue lipids and reduced glycogen content and insulin sensitivity. A low dose of melatonin was more effi cient than estrogen in reversing all the ovariectomy-induced changes. The combination of estrogen melatonin was found to be best in correcting glycemic dysregulation while high doses of melatonin could effectively regulate dyslipidemia. Conclusion The present study provides strong evidence for melatonin supplementation therapy to be more potent and effective in comparison to estrogen replacement therapy due to its single-handed ability to revert all the ovariectomy-induced changes. No reported side-effect or long-term effect of melatonin, against the known effects of estrogen replacement therapy, make it more attractive as a candidate to treat postmenopausal symptoms. en_US
dc.language.iso en en_US
dc.publisher International Menopause Society en_US
dc.subject Ovariectomy en_US
dc.subject Melatonin en_US
dc.subject Estrogen en_US
dc.subject Insulin Sensitivity en_US
dc.subject Dyslipidemia en_US
dc.title Melatonin supplementation therapy as a potent alternative to ERT in ovariectomized rats en_US
dc.type Article en_US


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