NAVRACHANA UNIVERSITY

Plasticity changes in adult metabolic homeostasis and tissue oxidative stress: neonatal programming by corticosterone and melatonin as deprogrammer

Show simple item record

dc.contributor.author Baxi, D. B.
dc.contributor.author Singh, Prem Kumar
dc.contributor.author Vachhrajani, Kauresh D.
dc.contributor.author A. V., Ramachandran
dc.date.accessioned 2016-03-12T06:39:24Z
dc.date.available 2016-03-12T06:39:24Z
dc.date.issued 2012
dc.identifier.citation D. Baxi , P. K. Singh , K. Vachhrajani and A. V. Ramachandran (2012) Plasticity changes in adult metabolic homeostasis and tissue oxidative stress: neonatal programming by corticosterone and melatonin as deprogrammer.The Journal of Maternal-Fetal and Neonatal Medicine, 2012; 25(6): 831–844. en_US
dc.identifier.issn 1476-7058 (Print)
dc.identifier.issn 1476-4954 (Online)
dc.identifier.other 0.3109/14767058.2011.599456
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/168
dc.description The Journal of Maternal-Fetal and Neonatal Medicine, 2012; 25(6): 831–844. doi: 10.3109/14767058.2011.599456 en_US
dc.description.abstract Objective: To evaluate the long-term plasticity changes induced by neonatal corticosterone programming on adult metabolic status and the deprogramming effect of melatonin. Methods: Male and female Wistar rats were maintained under standard conditions and when mated females delivered pups, neonates of both sexes were separated and equal number of pups was assigned to lactating mothers. Pups treated with saline, corticosterone or a combination of corticosterone and melatonin from PND 2 to PND 14, were maintained until 120 days of age. Various serum and tissue parameters pertaining to glycaemic regulation, dyslipidemia, hepatic and renal distress and oxidative stress were analyzed in adult rats. Results: Neonatal corticosterone exposure induced dyslipidemia, increased fed and fasting glucose levels, insulin resistance, lipid peroxidation, serum levels of insulin, corticosterone and hepatic and renal dysfunction markers and decreased the levels of enzymatic and non-enzymatic antioxidants, relatively more in males. Melatonin proved as an effective deprogrammer of corticosterone induced plasticity changes. Conclusions: Neonatal corticosterone exposure induces long lasting effects on adult physiology and metabolism. Concurrent treatment with melatonin effectively deprograms the changes. en_US
dc.language.iso en en_US
dc.publisher Informa UK, Ltd. en_US
dc.subject Melatonin en_US
dc.subject Corticosterone en_US
dc.subject Neonatal en_US
dc.subject Diabetes en_US
dc.subject Stress en_US
dc.title Plasticity changes in adult metabolic homeostasis and tissue oxidative stress: neonatal programming by corticosterone and melatonin as deprogrammer en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

  • Journal Papers [78]
    It contains all document related to this collection

Show simple item record

Search NUV Repository


Advanced Search

Browse

My Account