NAVRACHANA UNIVERSITY

Prior cadmium exposure improves glucoregulation in diabetic rats but exacerbates effects on metabolic dysregulation, oxidative stress and hepatic and renal toxicity.

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dc.contributor.author Singh, Prem Kumar
dc.contributor.author Baxi, Darshee
dc.contributor.author Diwedi, Ruchi
dc.contributor.author Ramachandran, A. V.
dc.date.accessioned 2016-03-12T09:12:42Z
dc.date.available 2016-03-12T09:12:42Z
dc.date.issued 2012
dc.identifier.citation Prem Kumar Singh., Darshee Baxi, Ruchi Diwedi and Ramachandran AV. Prior cadmium exposure improves glucoregulation in diabetic rats but exacerbates effects on metabolic dysregulation, oxidative stress and hepatic and renal toxicity. Drug Chem Toxicol. 2012 Apr;35(2):167-77. doi: 10.3109/01480545.2011.589450. Epub 2012 Jan 23. 2011 Impact Factor: 1.082 en_US
dc.identifier.issn 0148-0545 (Print)
dc.identifier.issn 1525-6014 (Online)
dc.identifier.other 10.3109/01480545.2011.589450
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/172
dc.description.abstract The present study was taken up to assess the role of subchronic exposure to an environmentally relevant dosage of cadmium in type l diabetes. Female rats of the Wistar strain were treated with cadmium (5.12 mg/kg body weight) for 45 days. On day 46, rats were made diabetic by alloxan. After 7 days, diabetes (i.e., animals with serum glucose greater than 300 mg/dL) in the alloxanized animals was confirmed and further experiments were conducted for 15 days. Cadmium pretreatment showed disturbed glucose homeostasis with attendant changes in carbohydrate metabolism, coupled with decrease in food and water intake. Disturbance in carbohydrate metabolism was indicated by altered tissue metabolite load, as marked by a decrease in protein and glycogen contents and increased cholesterol store. Poor glucose clearance subsequent to a glucose challenge under the glucose tolerance test was observed in these animals (0.48/min in control vs. 0.13/min in Cd animals). There was a significantly lower glucose elevation rate in the insulin response test subsequent to an insulin-induced decrease in glucose level in Cd-exposed animals. Elevated oxidative stress was marked by increased lipid peroxidation, decreased antioxidant (both nonenzymatic and enzymatic) levels, and serum markers of hepatic and renal damage. Decreased corticosterone levels, together with increased E2 and reduced P4 levels, were some of the hallmark changes in the serum hormone profile of Cd-exposed animals. Overall, the present results are novel and interesting to open more investigations on animal models of type 1 diabetes with a history of previous Cd exposure. en_US
dc.language.iso en en_US
dc.publisher Informa Healthcare USA, Inc en_US
dc.subject Cadmium en_US
dc.subject Diabetes en_US
dc.subject Oxidative stress en_US
dc.subject Glucoregulation en_US
dc.title Prior cadmium exposure improves glucoregulation in diabetic rats but exacerbates effects on metabolic dysregulation, oxidative stress and hepatic and renal toxicity. en_US
dc.type Article en_US


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