NAVRACHANA UNIVERSITY
Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model
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| dc.contributor.author | Singh, Prem Kumar | |
| dc.contributor.author | Baxi, Darshee | |
| dc.contributor.author | Banerjee, Sudip | |
| dc.contributor.author | Ramachandran, A.V. | |
| dc.date.accessioned | 2016-03-12T09:21:00Z | |
| dc.date.available | 2016-03-12T09:21:00Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Prem Kumar Singh, Darshee Baxi, Sudip Banerjee and A.V. Ramachandran.Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model.Experimental and Toxicologic Pathology. 2012 Jul;64(5):441-8. doi: 10.1016/j.etp.2010.10.011. Epub 2010 Nov 23. 2011 Impact Factor: 2.71 | en_US |
| dc.identifier.other | 10.1016/j.etp.2010.10.011 | |
| dc.identifier.uri | http://27.109.7.66:8080/xmlui/handle/123456789/173 | |
| dc.description.abstract | Methanolic extractsof Pterocarpus marsupium Roxb (P. marsupium) andOcimumsanctum Linn (O. sanctum) were preparedseparatelyandthenadministeredtobothnon-diabeticandalloxaninduceddiabeticadult female Wistarratsasamixtureofbothatadosageof500mg/kgbodyweight,anditseffectwaschecked on serumandtissuelipidstogetherwithcorticosterone,estrogenandprogesteroneprofile.Further,tissue load ofmetabolites(cholesterol),enzymaticandnon-enzymaticantioxidantstatustogetherwithlipid peroxidation levelsandserummarkersofhepaticandrenaldamagewerealsoassessed.Resultsofthe present studystronglysupportthepossibilityofthisherbalcombinationinhumanstomeettheobjective of achievingaholisticameliorationandcureofdiabetesas,theherbalextractmixtureof P. marsupium and O. sanctum has succeededinnotonlyrectifyingdyslipidemiabutalsoinrestoringtheendogenous antioxidant levelstotheprediabeticstatus.Herbalpreparationsareidealcandidatesofchoiceandin this context,thepresentcombinationof P. marsupium and O. sanctum provides compellingevidencefor a holisticefficacyinameliorationofassociateddiabeticmanifestations/dysregulations. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier GmbH | en_US |
| dc.subject | Diabetes | en_US |
| dc.subject | Herbal extract | en_US |
| dc.subject | Alloxan | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.title | Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model | en_US |
| dc.type | Article | en_US |
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