dc.contributor.author |
Singh, Prem Kumar |
|
dc.contributor.author |
Baxi, Darshee |
|
dc.contributor.author |
Doshi, Ankita |
|
dc.contributor.author |
Ramachandran, A.V. |
|
dc.date.accessioned |
2016-03-12T10:01:02Z |
|
dc.date.available |
2016-03-12T10:01:02Z |
|
dc.date.issued |
2011 |
|
dc.identifier.citation |
Singh, Prem Kumar; Baxi, Darshee; Doshi, Ankita; and A V, Ramachandran (2011) "Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats," Journal of Complementary and Integrative Medicine: Vol. 8: Iss. 1, Article 19. |
en_US |
dc.identifier.other |
10.2202/1553-3840.1533 |
|
dc.identifier.uri |
http://27.109.7.66:8080/xmlui/handle/123456789/176 |
|
dc.description.abstract |
The present study evaluates the efficacy of ethanolic extract of Boerhaavia diffusa L (BD)
administered orally at a dose of 500mg/kg body weight for a period of 30 days to alloxanized
diabetic rats and its efficacy compared with the standard hypoglycaemic drug metformin. Diabetic
animals showed glycemic dysregulation, altered ionic balance, increased levels of serum markers
of kidney function, and reduced Na+-K+ ATPase activity and endogenous antioxidant status.
Administration of BD not only maintained the ionic balance and renal Na+-K+ ATPase activity but
also significantly minimized diabetic hyperglycaemia. The renal antioxidant status (GPx, Catalase,
SOD and GSH) remained in the near normal range and LPO level lower than the non-diabetic
level. These effects are comparable to the changes brought about by metformin treatment and even
better. Over all, the present study provides evidence for BD to be a potent renoprotective and
antihyperglycaemic agent in diabetic animals. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Berkeley Electronic Press |
en_US |
dc.subject |
Boerhaavia diffusa L |
en_US |
dc.subject |
Diabetic nephropathy |
en_US |
dc.subject |
Metformin |
en_US |
dc.subject |
ATPase |
en_US |
dc.subject |
Renal dysfunction |
en_US |
dc.subject |
Hyperglycaemia |
en_US |
dc.title |
Antihyperglycaemic and renoprotective effect of boerhaavia diffusa L. in experimental diabetic rats |
en_US |
dc.type |
Article |
en_US |