NAVRACHANA UNIVERSITY

Antihyperglycaemic and renoprotective effect of boerhaavia diffusa L. in experimental diabetic rats

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dc.contributor.author Singh, Prem Kumar
dc.contributor.author Baxi, Darshee
dc.contributor.author Doshi, Ankita
dc.contributor.author Ramachandran, A.V.
dc.date.accessioned 2016-03-12T10:01:02Z
dc.date.available 2016-03-12T10:01:02Z
dc.date.issued 2011
dc.identifier.citation Singh, Prem Kumar; Baxi, Darshee; Doshi, Ankita; and A V, Ramachandran (2011) "Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats," Journal of Complementary and Integrative Medicine: Vol. 8: Iss. 1, Article 19. en_US
dc.identifier.other 10.2202/1553-3840.1533
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/176
dc.description.abstract The present study evaluates the efficacy of ethanolic extract of Boerhaavia diffusa L (BD) administered orally at a dose of 500mg/kg body weight for a period of 30 days to alloxanized diabetic rats and its efficacy compared with the standard hypoglycaemic drug metformin. Diabetic animals showed glycemic dysregulation, altered ionic balance, increased levels of serum markers of kidney function, and reduced Na+-K+ ATPase activity and endogenous antioxidant status. Administration of BD not only maintained the ionic balance and renal Na+-K+ ATPase activity but also significantly minimized diabetic hyperglycaemia. The renal antioxidant status (GPx, Catalase, SOD and GSH) remained in the near normal range and LPO level lower than the non-diabetic level. These effects are comparable to the changes brought about by metformin treatment and even better. Over all, the present study provides evidence for BD to be a potent renoprotective and antihyperglycaemic agent in diabetic animals. en_US
dc.language.iso en en_US
dc.publisher Berkeley Electronic Press en_US
dc.subject Boerhaavia diffusa L en_US
dc.subject Diabetic nephropathy en_US
dc.subject Metformin en_US
dc.subject ATPase en_US
dc.subject Renal dysfunction en_US
dc.subject Hyperglycaemia en_US
dc.title Antihyperglycaemic and renoprotective effect of boerhaavia diffusa L. in experimental diabetic rats en_US
dc.type Article en_US


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