Evaluation on the efficacy of a poly herbal supplement along with exercise in alleviating dyslipidemia, oxidative stress and hepatic and renal toxicity associated with type -1 diabetes

Abstract

Modification of dietary habits and life style changes such as, regular exercise together with mixed formulations containing blood sugar lowering herbs in combination with antioxidants and detoxicants, have been incorporated in the management of type -1 diabetes. Aqueous extract of 7 plants (Annona squamosa(Annonaceae), Cassia fistula, Coccinia indica, Mangifera indica, Ocimum sanctum, Lagerstroemia losflos-reginee, and Murraya koenigii) (PE) together with swimming exercise (S) has been employed in the present study to evaluate the efficacy against dyslipidemia and oxidative stress associated with type-1 diabetes. To this effect, adult albino rats were made diabetic (DC) by a single i.p injection of alloxan (120 mg / kg body weight). Animals having blood glucose level of 300 mg / dl or higher were considered diabetic. Control and experimental animals were supplemented with PE and subjected to swimming exercise of 30 minutes duration for 15 days. Animals were sacrificed on the 16th day and, various parameters related to oxidative stress (SOD, CAT, GPx, GSH and LPO) and lipid metabolism (Total lipids, TG, TC, LDL, VDL, and VLDL) were evaluated. Diabetic animals showed down regulated antioxidant defence and dysregulation of lipid metabolism. Both PE and S+PE restored the level of antioxidants and markers of lipid metabolism to near normal levels. Overall, the present study provides support and evidence for consideration of a therapeutic approach combining the beneficial effects of a polyherbal preparation in association with adaptive physical activity for alleviating symptoms of tissue oxidative damage and disorders of lipid metabolism.