Abstract:
Present study evaluates cardioprotective role of
melatonin (Mel), alpha lipoic acid (ALA), a combination of
melatonin and alpha lipoic acid (Mel ? ALA) against
cadmium (Cd)-induced oxidative damage. Female albino
rats were subjected to 15-day exposure to Cd (5.12 mg/kg
bw) alone or treated with ML (10 mg/kg bw) ? ALA
(25 mg/kg bw) simultaneously. Plasma markers of cardiac
damage, cardiac free radical generation, lipid peroxidation,
endogenous antioxidant status, cadmium load, metallothionein
induction, and histopathology were evaluated in
various experimental groups. Combination of Mel ? ALA
significantly prevented leakage of marker enzymes of
cardiac damage, changes in cardiac free radical generation,
endogenous antioxidants, antioxidant status, structural
alterations and augmented the degree of metallothionein
(MT) induction. The results demonstrate that ML ? ALA
co-administration effectively protected against Cd-induced
cardiac oxidative damage.
