NAVRACHANA UNIVERSITY

A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage

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dc.contributor.author Mukherjee, Raktim
dc.contributor.author Banerjee, Sudeep
dc.contributor.author Joshi, Niraj
dc.contributor.author Singh, Prem Kuma
dc.contributor.author Baxi, Darshee
dc.contributor.author Ramachandran, A. V.
dc.date.accessioned 2016-03-12T10:19:14Z
dc.date.available 2016-03-12T10:19:14Z
dc.date.issued 2010
dc.identifier.citation Raktim Mukherjee , Sudeep Banerjee , Niraj Joshi, Prem Kumar Singh, Darshee Baxi, A. V. Ramachandran(2010). A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage. 2011 Mar;11(1):78-88. doi: 10.1007/s12012-010-9092-9. Erratum in: Cardiovasc Toxicol. 2011 Mar;11(1):89-90. (Impact factor: 2.067) en_US
dc.identifier.issn 1530-7905
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/178
dc.description.abstract Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel ? ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) ? ALA (25 mg/kg bw) simultaneously. Plasma markers of cardiac damage, cardiac free radical generation, lipid peroxidation, endogenous antioxidant status, cadmium load, metallothionein induction, and histopathology were evaluated in various experimental groups. Combination of Mel ? ALA significantly prevented leakage of marker enzymes of cardiac damage, changes in cardiac free radical generation, endogenous antioxidants, antioxidant status, structural alterations and augmented the degree of metallothionein (MT) induction. The results demonstrate that ML ? ALA co-administration effectively protected against Cd-induced cardiac oxidative damage. en_US
dc.language.iso en en_US
dc.publisher Springer Science+Business Media en_US
dc.subject Cadmium en_US
dc.subject Metallothionein en_US
dc.subject Melatonin en_US
dc.subject Alpha lipoic acid en_US
dc.subject Cardiotoxicity en_US
dc.title A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage en_US
dc.type Article en_US


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