NAVRACHANA UNIVERSITY

Synthesis and preclinical characterization of a cationic iodinated imaging contrast agent (CA4+) and its use for quantitative computed tomography of ex vivo human hip cartilage

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dc.contributor.author Stewart, Rachel C.
dc.contributor.author Patwa, Amit N.
dc.contributor.author Lusic, Hrvoje
dc.contributor.author Freedman, Jonathan D.
dc.contributor.author Wathier, Michel
dc.contributor.author Snyder, Brian D.
dc.contributor.author Guermazi, Ali
dc.contributor.author Grinstaff, Mark W.
dc.date.accessioned 2019-06-13T05:30:15Z
dc.date.available 2019-06-13T05:30:15Z
dc.date.issued 2017-06-15
dc.identifier.issn 0022-2623 (P-ISSN)
dc.identifier.issn 1520-4804 (E-ISSN)
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/574
dc.description Journal of Medicinal Chemistry, Vol-60, Issue-13, 2017, p. 5543-5555 en_US
dc.description.abstract Contrast agents that go beyond qualitative visualization and enable quantitative assessments of functional tissue performance represent the next generation of clinically useful imaging tools. An optimized and efficient large-scale synthesis of a cationic iodinated contrast agent (CA4+) is described for imaging articular cartilage. Contrast-enhanced CT (CECT) using CA4+ reveals significantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic or nonionic agents, and CA4+ uptake follows Donnan equilibrium theory. The CA4+ CECT attenuation obtained from imaging ex vivo human hip cartilage correlates with the glycosaminoglycan content, equilibrium modulus, and coefficient of friction, which are key indicators of cartilage functional performance and osteoarthritis stage. Finally, preliminary toxicity studies in a rat model show no adverse events, and a pharmacokinetics study documents a peak plasma concentration 30 min after dosing, with the agent no longer present in vivo at 96 h via excretion in the urine. en_US
dc.language.iso en_US en_US
dc.publisher American Chemical Society Publications en_US
dc.subject Contrast agent en_US
dc.subject Articular cartilage en_US
dc.subject Computed tomography en_US
dc.subject Glycosaminoglycan en_US
dc.title Synthesis and preclinical characterization of a cationic iodinated imaging contrast agent (CA4+) and its use for quantitative computed tomography of ex vivo human hip cartilage en_US
dc.type Article en_US


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