Abstract:
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single
fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido
thymidine as starting material. Physicochemical studies (surface tension measurements,
differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature
endothermic phase transition temperatures like the previously reported double chain
glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower lim) compared to the first generation of GNFs.
Description:
Molecules, Vol-18, Issue-10, 2013, p. 12241-12263