Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids

dc.contributor.author	Patwa, Amit
dc.contributor.author	Salgado, Gilmar
dc.contributor.author	Dole, François
dc.contributor.author	Navailles, Laurence
dc.contributor.author	Barthélémy, Philippe
dc.date.accessioned	2019-06-13T07:48:53Z
dc.date.available	2019-06-13T07:48:53Z
dc.date.issued	2013
dc.identifier.issn	1477-0520 (P-ISSN)
dc.identifier.issn	1477-0539 (E-ISSN)
dc.identifier.uri	http://27.109.7.66:8080/xmlui/handle/123456789/579
dc.description	Organic & Biomolecular Chemistry, Vol-11, 2013, p. 7108-7112	en_US
dc.description.abstract	Hybrid nucleotide-lipids containing locked nucleic acid (LNA) show enhanced hybridization properties with complementary single strand RNAs compared to DNA lipid analogues. The LNA adenosine lipid features unique binding properties with a high binding affinity for poly-uridine and the entropically driven formation of a stable complex (Kd ≈ 43 nM). Enhanced hybridization properties of LNA-based lipids should be applicable for the development of oligonucleotide (ON) delivery systems or as small molecule binders to RNA for novel therapeutic strategies.	en_US
dc.language.iso	en_US	en_US
dc.publisher	RSC Publishing	en_US
dc.subject	Locked nucleic acid (LNA)	en_US
dc.subject	Amphiphiles	en_US
dc.subject	Self-assemblies	en_US
dc.subject	Lipid-oligonucleotide	en_US
dc.subject	Isothermal titration calorimetry	en_US
dc.title	Tuning molecular interactions in lipid-oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids	en_US
dc.type	Article	en_US