Abstract:
The construction of new nanotools is presented here using the example of fluorescent semiconductor nanocrystals, quantum dots (QDs). In this study, the implementation
of the new lipid oligonucleotide conjugate-functionalized quantum dots (LON-QDs) is realized in four steps: (i) the synthesis of the lipid oligonucleotide conjugates (LONs), (ii)
the encapsulation of QDs by nucleolipids and LONs, (iii) the study of the duplex formation of LON-QDs with the complementary ON partners, and (iv) the cellular uptake of
the LON-QD platform and hybridization with the target ONs (microRNA and miR-21).
Description:
Bioconjugate Chemistry, Vol-24, Issue-8, 2013, p. 1345-1355