NAVRACHANA UNIVERSITY

Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage

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dc.contributor.author Banerjee, Sudip
dc.contributor.author Joshi, Niraj
dc.contributor.author Mukherjee, Raktim
dc.contributor.author Singh, Prem Kumar
dc.contributor.author Baxi, Darshee
dc.contributor.author Ramachandran, A.V.
dc.date.accessioned 2021-08-02T07:07:17Z
dc.date.available 2021-08-02T07:07:17Z
dc.date.issued 2017
dc.identifier.citation Banerjee, Sudip & Joshi, Niraj & Mukherjee, Raktim & Kumar, Prem & Baxi, Dr. Darshee & A.V., Ramachandran. (2017). Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage. Interdisciplinary Toxicology. 10. 10.1515/intox-2017-0003. en_US
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/665
dc.description.abstract The present study was undertaken to assess the degree of oxidative stress and toxic effects induced by chromium on hepatic tissue in male Wistar rats exposed to a realistic dosage of Cr(VI) (20 mg/kg/b.w./day) through drinking water, based on the levels of these metals found in the environment, for a duration of 15, 30 and 60 days. The protective effect of melatonin (10 mg/kg) was also studied by simultaneous administration with the metal. Levels of enzymatic and non-enzymatic antioxidants as well as lipid peroxidation were assessed. There was a significant decrease in enzymatic as well as non-enzymatic antioxidants and an increase in the lipid peroxidation level, which were prevented and maintained at near-normal levels by the administration of melatonin in all treatment periods. Metal accumulation was maximal at 15 days, with gradual decreases till 60 days. Histopathological observations also demonstrated the fact that Cr (VI) exposure leads to cytological lesions in the hepatic tissue promoting cellular necrotic/apoptotic changes, while melatonin was able to counteract insults induced by Cr (VI) at all treatment periods. It also prevented alterations in insulin and glucose levels. Overall, the present study suggests a duration-dependent effect of Cr on hepatic oxidative stress and cytotoxicity and shows the potent activity of melatonin in preventing the negative effects of Cr (VI). en_US
dc.language.iso en en_US
dc.publisher Interdisciplinary toxicology en_US
dc.subject Melatonin en_US
dc.subject Oxidative Stress en_US
dc.subject Toxicity en_US
dc.subject Chromium (VI) en_US
dc.title Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage en_US
dc.type Article en_US


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