NAVRACHANA UNIVERSITY

Derivatives of dapsone (dap): synthesis and study on in vitro anticancer activity and dna laddering against hep g2 and c6 human cancer cell lines

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dc.contributor.author Pillai, Vineeta
dc.contributor.author Kadu, Rahul
dc.contributor.author Buch, Lipi
dc.contributor.author Singh, Vinay K.
dc.date.accessioned 2021-12-16T06:54:43Z
dc.date.available 2021-12-16T06:54:43Z
dc.date.issued 2017-05
dc.identifier.issn 4382 – 4391
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/764
dc.description 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, ChemistrySelect 2017, 2, 4382 – 4391 en_US
dc.description.abstract Interesting biological profile of dapsone (dap) has encouraged us to derivatize it further into a novel series of diamines 4,4’-bis (2-(alkylamino) acetamido) diphenylsulfone L1 -L3 and their ensuing metallomacrocyclic complexes of the type [M2-m2 -bis- {(k2 S,S-S2CN(R)CH2CONHC6H4)2SO2}] {R=Cy, M=NiII 1 a, CuII 1 b, ZnII 1 c; R=i Pr, M=NiII 2 a, CuII 2 b, ZnII 2 c; R=n Bu, M=NiII 3 a, CuII 3 b, ZnII 3 c}. These compounds were characterized by standard spectroscopic methods. A DFT level calculation has been performed on selected compounds. In vitro anticancer activity against Hep G2 (hepatoma) and C6 (Glioblastoma) cell lines suggests specificity of these compounds for cancer cells over normal liver cells. Interestingly, complex 2c holding zinc(II) and Ni Pr substituents shows nearly 3 fold better cytotoxic activity against both Hep G2 (8.470.016 mg/mL) and C6 (4.3 0.019 mg/mL) cell lines, compared to the reference drug Cisplatin. The morphological changes and moderate to heavy DNA laddering clearly demonstrate the induction of apoptotic cell death, required for major chemical therapeutic implications. en_US
dc.language.iso en en_US
dc.publisher Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim en_US
dc.subject alkylamino en_US
dc.subject diphenylsulfone en_US
dc.subject spectroscopic methods en_US
dc.subject hepatoma en_US
dc.subject morphological en_US
dc.title Derivatives of dapsone (dap): synthesis and study on in vitro anticancer activity and dna laddering against hep g2 and c6 human cancer cell lines en_US
dc.type Article en_US


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