NAVRACHANA UNIVERSITY

Binuclear diphenyltin(IV)dithiocarbamate complexes bearing functionalized linkers: Synthesis, spectral characterization, DFT and in vitro anticancer activity

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dc.contributor.author Pillai, Vineeta
dc.contributor.author Patel, Shailykumari K.
dc.contributor.author Buch, Lipi
dc.contributor.author Sing, Vinay K
dc.date.accessioned 2021-12-16T07:23:15Z
dc.date.available 2021-12-16T07:23:15Z
dc.date.issued 2018-10
dc.identifier.issn 32(12), e4559
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/765
dc.description Applied Organometallic Chemistry, Vol 32, Issue 12, 2018 en_US
dc.description.abstract A new series of diphenyltin(IV)dithiocarbamate complexes of the type [(Ph2Sn)2-μ2-bis{(κ2S,S-S2CN(R)CH2CONHC6H4)2SO2}] {R = Cy (1), iPr (2), nBu (3)} and [(Ph2Sn)2-μ2-bis{(κ2S,S-S2CN(R)CH2CONH)2C6H4}] {R = Cy (4), iPr (5)} has been efficiently synthesized and characterized by the relevant spectroscopic (1H, 13C, 1H DOSY, 119Sn NMR, ESI MS, UV–visible absorption, IR) and thermogravimetric methods. Density functional theory level calculations have been carried out to reinforce the experimental data. Compounds have been screened for their in vitro anticancer ability against a malignant human tumor HepG2 (hepatoma) cell line by MTT assay. Remarkably, the anticancer activities of binuclear organotin(IV)dithiocarbamate complexes 1–5 are evidently boosted as high as 22-fold in 1 (3.32 ± 0.14 μM), 44-fold in 2 (1.77 ± 0.11 μM), 37-fold in 3 (2.02 ± 0.47 μM), 8 fold in 4 (8.72 ± 0.19 μM) and 29-fold in 5 (2.60 ± 0.67 μM), compared with the reference drug cisplatin (75.67 ± 0.51 μM). Morphological proofs like shrinking of cells specifies the induction of apoptosis as part of the mechanism of action of these compounds, which is further reinforced by the individual staining of the cells by acridine orange/ethidium bromide. en_US
dc.language.iso en en_US
dc.publisher Applied Organometallic Chemistry en_US
dc.subject dithiocarbamate en_US
dc.subject thermogravimetric en_US
dc.subject hepatoma en_US
dc.subject acridine en_US
dc.subject thermogravimetric en_US
dc.title Binuclear diphenyltin(IV)dithiocarbamate complexes bearing functionalized linkers: Synthesis, spectral characterization, DFT and in vitro anticancer activity en_US
dc.type Article en_US


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