Rapid, effective deprotection of tert-butoxycarbonyl (boc) amino acids and peptides at high temperatures using a thermally stable ionic liquid

dc.contributor.author	Bhawal, Sumit S
dc.contributor.author	Patil, Rahul A
dc.contributor.author	Armostrong, Dainiel W
dc.date.accessioned	2021-12-16T10:11:29Z
dc.date.available	2021-12-16T10:11:29Z
dc.date.issued	2015-10
dc.identifier.issn	1946-6234(Print)
dc.identifier.issn	1946-6242(Online)
dc.identifier.uri	http://27.109.7.66:8080/xmlui/handle/123456789/768
dc.description	Electronic Supplementary Material (ESI) for RSC Advances. This journal is © The Royal Society of Chemistry 2015	en_US
dc.description.abstract	A method for high temperature Boc deprotection of amino acids and peptides in a phosphonium ionic liquid is described. The ionic liquid had low viscosity, high thermal stability and demonstrated a beneficial effect. The study extended the possibility for extraction of water soluble polar organic molecules using ionic liquids. Trace water significantly improved product purity and yield, while only 2 equiv. TFA led to deprotection within 10 min. The trityl group was also deprotected.	en_US
dc.language.iso	en	en_US
dc.publisher	Electronic Supplementary Material (ESI) for RSC Advances	en_US
dc.subject	Boc deprotection	en_US
dc.subject	phosphonium	en_US
dc.subject	deprotection	en_US
dc.subject	trityl	en_US
dc.subject	deprotected.	en_US
dc.title	Rapid, effective deprotection of tert-butoxycarbonyl (boc) amino acids and peptides at high temperatures using a thermally stable ionic liquid	en_US
dc.type	Article	en_US