NAVRACHANA UNIVERSITY

β-cell replenishment: Possible curative approaches for diabetes mellitus

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dc.contributor.author Rathva, Nirali
dc.contributor.author Patel, Roma
dc.contributor.author Palil, Sayantani Pramanik
dc.contributor.author Parmar, Nishant
dc.contributor.author Rana, Sneha
dc.contributor.author Ansari, Mohammad Isamil
dc.contributor.author Ramchandran, A.V.
dc.contributor.author Begum, Rasheedunnisa
dc.date.accessioned 2021-12-17T06:56:44Z
dc.date.available 2021-12-17T06:56:44Z
dc.date.issued 2020-10
dc.identifier.issn 0939-4753
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/776
dc.description Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 11, 30 October 2020, Pages 1870-1881 en_US
dc.description.abstract Aims Diabetes mellitus (DM) is a disorder of heterogeneous etiology marked by persistent hyperglycemia. Exogenous insulin is the only treatment for type 1 diabetes (T1D). Islet transplantation is a potential long cure for T1D but is disapproved due to the possibility of immune rejection in the later stage. The approaches used for treating type 2 diabetes (T2D) include diet restrictions, weight management and pharmacological interventions. These procedures have not been able to boost the quality of life for diabetic patients owing to the complexity of the disorder. Data synthesis Hence, research has embarked on permanent ways of managing, or even curing the disease. One of the possible approaches to restore the pancreas with new glucose-responsive β-cells is by their regeneration. Regeneration of β-cells include islet neogenesis, dedifferentiation, and trans-differentiation of the already differentiated cells. Conclusions This review briefly describes the islet development, functions of β-cells, mechanism and factors involved in β-cell death. It further elaborates on the potential of the existing and possible therapeutic modalities involved in the in-vivo replenishment of β-cells with a focus on exercise, diet, hormones, small molecules, and phytochemicals. en_US
dc.language.iso en en_US
dc.publisher Nutrition, Metabolism and Cardiovascular Diseases en_US
dc.subject Pancreas en_US
dc.subject β-cell apoptosis en_US
dc.subject β-cell regeneration en_US
dc.subject Islet neogenesis en_US
dc.subject α-to-β trans-differentiation en_US
dc.subject Regenerative medicine en_US
dc.title β-cell replenishment: Possible curative approaches for diabetes mellitus en_US
dc.type Article en_US


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