NAVRACHANA UNIVERSITY

17β-estradiol modulates NGF and BDNF expression through ERβ mediated ERK signaling in cortical astrocytes

Show simple item record

dc.contributor.author Langhnoja, J M
dc.contributor.author L. K, Buch
dc.contributor.author Pillai, P P
dc.date.accessioned 2021-12-20T09:45:03Z
dc.date.available 2021-12-20T09:45:03Z
dc.date.issued 2018-08
dc.identifier.issn 3015-3027
dc.identifier.uri http://27.109.7.66:8080/xmlui/handle/123456789/786
dc.description Biologia volume 73, 907–915 (2018) en_US
dc.description.abstract 17β-estradiol is known to exert neurotrophic and neuroprotective effects through classical estrogen receptors [ERs], ERα and ERβ, on a variety of cell types either by genomic or non-genomic actions. The actions of estradiol on glial cells are important to maintain metabolic functions of the nervous system. Astrocytes are considered to be active participants in brain activity because of their ability to release growth factors, including neurotrophins. Present in vitro studies show that 17β-estradiol modulates NGF and BDNF expression in time-dependent manner and ERK acts as secondary messenger for estradiol’s action. 17β-estradiol is involved in survival of cortical astrocytes. In conclusion, this study indicates vital role of ERβ mediated ERK signalling for regulation of NGF and BDNF expression along with cell viability of cortical astrocytes which further confirms the role of ERs, particularly ERβ in glial cells’ functions and viability. en_US
dc.language.iso en en_US
dc.publisher Biologia volume en_US
dc.subject neurotrophic en_US
dc.subject neurotrophins; en_US
dc.subject astrocytes en_US
dc.subject signalling en_US
dc.title 17β-estradiol modulates NGF and BDNF expression through ERβ mediated ERK signaling in cortical astrocytes en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

  • Journal Papers [78]
    It contains all document related to this collection

Show simple item record

Search NUV Repository


Advanced Search

Browse

My Account